This course provides an overview of nuclear physics and the interactions of ionizing radiation with matter as applicable to nuclear medicine. Instrumentation examines the theories and operating principles of radiation detection instruments routinely used within nuclear medicine.
Course Objectives
Upon completion of this course, participants will be able to:
1. Explain the physical structure and properties of atoms.
2. Define and explain radiation, radioactive decay and the characteristics of radioactivity
3. List and explain the different methods of production of radionuclides.
4. List and explain the different types of interactions of radiation with matter.
5. Describes the types and uses of gas-filled radiation detectors.
6. Describe theory and operating principles of common scintillation detectors.
7. Explain the function and application of personnel monitoring devices.
8. Describe specific characteristics of alpha and beta emitting radioactivity
Radiation Biology examines the biological effects of ionizing radiation. Physical interactions, energy deposition and chemical changes that result in cell damage will be reviewed. The effects of these interactions on mammalian cells will be the main emphasis including survival and repair, mutagenesis and acute and late effects.
Course Objectives
Upon completion of this course, participants will be able to:
1. Differentiate between radioactivity and radiation
2. Explain the physical effects of ionizing radiation
3. Describe the chemical effects of radiation
4. Explain the biological effects of radiation on mammalian cells
5. Discuss the biological effects of low levels of ionizing radiation
6. Discuss the biological effects of high levels of ionizing radiation
A radiochemical is a chemical substance containing radioactive atoms within its structure. A radiochemical becomes a radiopharmaceutical when it has been tested for human use and meets the requirements of the US FDA. Radiopharmaceuticals range from simple elemental substances to complex radiolabeled molecules, cellular elements and particles.
Course Objectives
Upon completion of this course, participants will be able to:
1. Define the ideal characteristics of a radiopharmaceutical.
2. List three differences between diagnostic and therapeutic radiopharmaceuticals.
3. List the mechanisms of localization of radiopharmaceuticals.
4. Discuss the different types of labeling with radiotracers.
5. Discuss four concerns of solution chemistry of tracer metals.
6. Explain the radiolabeling of ligands with technetium.
7. Define impurities found in technetium labeled radiopharmaceuticals.
8. Discuss the chemical radiolabeling of ligands with other radiometals.
9. Explain the differences in radiolabeling with iodine.
10. List the steps in radiolabeling with positron emitters.
The Nuclear Regulatory Commission (NRC) stipulates that any individual qualified to be named as an Authorized User should have a working knowledge of radiation safety regulations and associated proactive measures. This course will review basic information specific to the handling of radioactive materials for human medical use. To successfully complete course, participants must complete all online modules and the laboratory components as outlined in the Lab Workbook.
Course Objectives
Upon completion of this course, participants will be able to:
1. Define radiation dose measurements.
2. Identify and describe the regulatory agencies governing radiopharmacy and the medical use of radioactive materials.
3. Describe and explain the principles of radiation protection.
4. Discuss personnel monitoring and precautions.
5. Explain area monitoring.
6. Discuss regulations concerning sealed references sources.
7. Explain the preparation and handling of packages containing radioactivity.
8. Describe procedures for the handling and disposal of radioactive and biohazard waste.